Loss-of-function variants in ABCA7 confer risk of Alzheimer’s disease
dc.contributor.author | Steinberg, Stacy | |
dc.contributor.author | Stefansson, Hreinn | |
dc.contributor.author | Jonsson, Thorlakur | |
dc.contributor.author | Johannsdottir, Hrefna | |
dc.contributor.author | Ingason, Andrés | |
dc.contributor.author | Helgason, Hannes | |
dc.contributor.author | Sulem, Patrick | |
dc.contributor.author | Magnusson, Olafur Th | |
dc.contributor.author | Gudjunsson, Sigurjon A | |
dc.contributor.author | Unnsteinsdottir, Unnur | |
dc.contributor.author | Kong, Augustine | |
dc.contributor.author | Helisalmi, Seppo | |
dc.contributor.author | Soininen, Hilkka | |
dc.contributor.author | Lah, James J | |
dc.contributor.author | Aarsland, Dag | |
dc.contributor.author | Fladby, Tormod | |
dc.contributor.author | Ulstein, Ingun | |
dc.contributor.author | Djurovic, Srdjan | |
dc.contributor.author | Sando, Sigrid Botne | |
dc.contributor.author | White, Linda | |
dc.contributor.author | Knudsen, Gun Peggy | |
dc.contributor.author | Westlye, Lars Tjelta | |
dc.contributor.author | Selbæk, Geir | |
dc.contributor.author | Giegling, Ina | |
dc.contributor.author | Hampel, Harald | |
dc.contributor.author | Hiltunen, Mikko | |
dc.contributor.author | Levey, AIlan I. | |
dc.contributor.author | Andreassen, Ole Andreas | |
dc.contributor.author | Rujescu, Dan | |
dc.contributor.author | Jonsson, Palmi V. | |
dc.contributor.author | Bjornsson, Sigurbjorn | |
dc.contributor.author | Snaedal, Jon | |
dc.contributor.author | Stefánsson, Kári | |
dc.date.accessioned | 2015-04-14T11:16:10Z | |
dc.date.accessioned | 2015-08-13T07:26:04Z | |
dc.date.available | 2015-04-14T11:16:10Z | |
dc.date.available | 2015-08-13T07:26:04Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Nature Genetics 2015 | |
dc.identifier.issn | 1546-1718 | |
dc.identifier.uri | http://hdl.handle.net/11250/296499 | |
dc.description | - | |
dc.description.abstract | We conducted a search for rare, functional variants altering susceptibility to Alzheimer’s disease that exploited knowledge of common variants associated with the same disease. We found that loss-of-function variants in ABCA7 confer risk of Alzheimer’s disease in Icelanders (odds ratio (OR) = 2. 2, P = 2.2× 10- 3) and discovered that the association replicated in study groups from Europe and the United States (combined OR = 2.03, P = 6.8×10-5). | |
dc.language.iso | eng | |
dc.title | Loss-of-function variants in ABCA7 confer risk of Alzheimer’s disease | |
dc.type | Journal article | |
dc.date.updated | 2015-04-14T11:16:10Z | |
dc.identifier.doi | doi:10.1038/ng.3246 | |
dc.identifier.cristin | 1234523 |
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