Browsing Norwegian Institute of Public Health Open Repository by Author "Sandin, Randi Helene"
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A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells
Michaelsen, Terje Einar; Thommesen, John E.; Ihle, Øistein; Gregers, Tone F.; Sandin, Randi Helene; Brekke, Ole Henrik; Sandlie, Inger (Peer reviewed; Journal article, 2006)There are potentially two binding sites for C1q on IgG, one on each C(H)2 domain of the gamma heavy chains, close to the lower hinge region. It is not clear whether the presence and involvement of both the C1q binding sites ... -
Human secretory IgM antibodies activate human complement and offer protection at mucosal surface
Michaelsen, Terje Einar; Emilsen, Sidsel; Sandin, Randi Helene; Granerud, Beathe Kiland; Bratlie, Diane Lynn Bryant; Ihle, Øistein; Sandlie, Inger (Peer reviewed; Journal article, 2016)