Blar i Norwegian Institute of Public Health Open Repository på forfatter "Brekke, Ole Henrik"
-
A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells
Michaelsen, Terje Einar; Thommesen, John E.; Ihle, Øistein; Gregers, Tone F.; Sandin, Randi Helene; Brekke, Ole Henrik; Sandlie, Inger (Peer reviewed; Journal article, 2006)There are potentially two binding sites for C1q on IgG, one on each C(H)2 domain of the gamma heavy chains, close to the lower hinge region. It is not clear whether the presence and involvement of both the C1q binding sites ...