Browsing Norwegian Institute of Public Health Open Repository by Author "Alehagen, Urban"
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Coenzyme Q10 supplementation – In ageing and disease
Aaseth, Jan; Alexander, Jan; Alehagen, Urban (Peer reviewed; Journal article, 2021)Abstract Coenzyme Q10 (CoQ10) is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells produce CoQ10 by a specialized cytoplasma ... -
Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders (Peer reviewed; Journal article, 2019) -
Decreased Concentration of Fibroblast Growth Factor 23 (FGF-23) as a Result of Supplementation with Selenium and Coenzyme Q10 in an Elderly Swedish Population: A Sub-Analysis
Alehagen, Urban; Aaseth, Jan Olav; Larsson, Anders; Alexander, Jan (Peer reviewed; Journal article, 2022) -
Dietary supplementation with selenium and coenzyme Q10 prevents increase in plasma D-dimer while lowering cardiovascular mortality in an elderly swedish population
Alehagen, Urban; Aaseth, Jan; Lindahl, Tomas L.; Larsson, Anders; Alexander, Jan (Peer reviewed; Journal article, 2021)A low intake of selenium is associated with increased cardiovascular mortality. This could be reduced by supplementation with selenium and coenzyme Q10. D-dimer, a fragment of fibrin mirroring fibrinolysis, is a biomarker ... -
Diets and drugs for weight loss and health in obesity - An update
Aaseth, Jan Olav; Ellefsen, Stian; Alehagen, Urban; Sundfør, Tine Mejlbo; Alexander, Jan (Peer reviewed; Journal article, 2021)Numerous combinations of diets and pharmacological agents, including lifestyle changes, have been launched to treat obesity. There are still ambiguities regarding the efficacies of different approaches despite many clinical ... -
Diets and drugs for weight loss and health in obesity – An update
Aaseth, Jan; Ellefsen, Stian; Alehagen, Urban; Sundfør, Tine M.; Alexander, Jan (Peer reviewed; Journal article, 2021)Numerous combinations of diets and pharmacological agents, including lifestyle changes, have been launched to treat obesity. There are still ambiguities regarding the efficacies of different approaches despite many clinical ... -
Early nutritional interventions with zinc, selenium and vitamin D for raising anti-viral resistance against progressive COVID-19
Alexander, Jan; Tinkov, Alexey A.; Strand, Tor A; Alehagen, Urban; Skalny, Anatoly V.; Aaseth, Jan (Peer reviewed; Journal article, 2020)Objectives: The novel coronavirus infection (COVID-19) conveys a serious threat globally to health and economy because of a lack of vaccines and specific treatments. A common factor for conditions that predispose for serious ... -
Impact of selenium on biomarkers and clinical aspects related to ageing. A review
Alehagen, Urban; Opstad, Trine B.; Alexander, Jan; Larsson, Anders; Aaseth, Jan (Peer reviewed; Journal article, 2021)Selenium (Se) is an essential dietary trace element that plays an important role in the prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins contain selenocysteine in the active center ... -
Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden
Alehagen, Urban; Johansson, Peter; Svensson, Erland; Aaseth, Jan; Alexander, Jan (Peer reviewed; Journal article, 2022)Purpose Selenium and coenzyme Q10 have synergistic antioxidant functions. In a four-year supplemental trial in elderly Swedes with a low selenium status, we found improved cardiac function, less cardiac wall tension and ... -
Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Brismar, Kerstin (Peer reviewed; Journal article, 2017) -
Increased SIRT1 Concentration Following Four Years of Selenium and Q<inf>10</inf> Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2023) -
Selenium and coenzyme Q<inf>10</inf> improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals
Dunning, Belinda J.; Bourgonje, Arno R.; Bulthuis, Marian L.C.; Alexander, Jan; Aaseth, Jan; Larsson, Anders; van Goor, Harry; Alehagen, Urban (Peer reviewed; Journal article, 2023) -
Selenium and Coenzyme Q<inf>10</inf> Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2022) -
Selenium and coesnzyme q10 supplementation improves renal function in elderly deficient in selenium: Observational results and results from a subgroup analysis of a prospective randomised double-blind placebo-controlled trial
Alehagen, Urban; Aaseth, Jan; Alexander, Jan; Brismar, Kerstin; Larsson, Anders (Peer reviewed; Journal article, 2020)A low selenium intake is found in European countries, and is associated with increased cardiovascular mortality. There is an association between selenium level and the severity of kidney disease. An association between ... -
Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Wågsäter, Dick (Peer reviewed; Journal article, 2017)Background Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with ... -
Significant changes in metabolic profiles after intervention with selenium and coenzyme q10 in an elderly population
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Surowiec, Izabella; Lundstedt-Enkel, Katrin; Lundstedt, Torbjörn (Peer reviewed; Journal article, 2019) -
Significant decrease of von Willebrand factor and plasminogen activator inhibitor-1 by providing supplementation with selenium and coenzyme Q10 to an elderly population with a low selenium status
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, A.; Lindahl, T. L. (Peer reviewed; Journal article, 2020) -
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
Alehagen, Urban; Aaseth, Jan; Alexander, Jan; Johansson, Peter (Peer reviewed; Journal article, 2018)Selenium and coenzyme Q10 are both necessary for optimal cell function in the body. The intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases. Therefore, an intervention ... -
Supplemental selenium and coenzyme Q10 reduce glycation along with cardiovascular mortality in an elderly population with low selenium status – A four-year, prospective, randomised, double-blind placebo-controlled trial
Alehagen, Urban; Aaseth, Jan Olav; Alexander, Jan; Johansson, Peter; Larsson, Anders (Peer reviewed; Journal article, 2020)Background:A low intake of selenium has been shown to increase the risk of cardiovascular mortality, andsupplementation of selenium and coenzyme Q10 influences this. The mechanism behind is unclear althougheffects on ... -
Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status. A Secondary Analysis of a Randomised Clinical Trial
Alehagen, Urban; Alexander, Jan; Aaseth, Jan (Journal article, 2016)Background Selenium is needed by all living cells in order to ensure the optimal function of several enzyme systems. However, the selenium content in the soil in Europe is generally low. Previous reports indicate that a ...