Browsing Folkehelseinstituttet by Journals "European Journal of Immunology"
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A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells
(Peer reviewed; Journal article, 2006)There are potentially two binding sites for C1q on IgG, one on each C(H)2 domain of the gamma heavy chains, close to the lower hinge region. It is not clear whether the presence and involvement of both the C1q binding sites ...