Vis enkel innførsel

dc.contributor.authorRongsen-Chandola, Temsunaro
dc.contributor.authorWinje, Brita Askeland
dc.contributor.authorGoyal, Nidhi
dc.contributor.authorRathore, Sudeep Singh
dc.contributor.authorMahesh, Madhu
dc.contributor.authorRanjan, Rajat
dc.contributor.authorArya, Alok
dc.contributor.authorRafiqi, Farhana Afzal
dc.contributor.authorBhandari, Nita
dc.contributor.authorStrand, Tor
dc.date.accessioned2015-11-26T13:01:31Z
dc.date.accessioned2016-01-08T14:55:53Z
dc.date.available2015-11-26T13:01:31Z
dc.date.available2016-01-08T14:55:53Z
dc.date.issued2014
dc.identifier.citationTrials 2014, 15
dc.identifier.issn1745-6215
dc.identifier.urihttp://hdl.handle.net/11250/2373183
dc.description-
dc.description.abstractBackground: Neutralizing antibodies in breast milk may adversely influence the immune response to live oral vaccines. Withholding breastfeeding around the time of vaccine administration has been suggested for improving vaccine performance. However, we do not know whether mothers find withholding breastfeeding around the time of vaccination acceptable and how they perceive this recommendation. Methods: In a clinical study designed to examine predictors of poor immune response to rotavirus vaccine in infants in India, Rotarix® was administered to infants at 6 and 10 weeks with other childhood vaccines. For the study, 400 mother–infant pairs were randomized into two groups in a 1:1 ratio. Mothers were either recommended to withhold breastfeeding or were encouraged to breastfeed half an hour before and after administration of Rotarix®. The mother–infant pairs were observed and the breastfeeding intervals were recorded during this period. Mothers were administered a questionnaire about their perception of the intervention after the infants received the second dose of Rotarix®. Results: Almost 98% (391/400) of the infants received both doses of Rotarix®. Adherence to the recommendations was high in both groups. All mothers in the group who were asked to withhold breastfeeding did so, except one who breastfed her infant before the recommended time after the first dose of Rotarix®. Of the mothers, 4% (7/195) reported that the recommendation to withhold breastfeeding was difficult to follow. All mothers in this group reported that they would withhold breastfeeding at the time of vaccination if they were asked to by a health-care provider. Only one mother responded that withholding breastfeeding would be a reason for not giving rotavirus vaccine to her infant. Conclusions: Withholding breastfeeding half an hour before and after vaccination appears to be acceptable to mothers in this setting. If withholding breastfeeding produces an improvement in the performance of the vaccine, it could be used to increase the public health impact of rotavirus immunization.
dc.language.isoeng
dc.relation.urihttp://www.trialsjournal.com/content/pdf/1745-6215-15-256.pdf
dc.titleCompliance of mothers following recommendations to breastfeed or withhold breast milk during rotavirus vaccination in North India: A randomized clinical trial
dc.typeJournal article
dc.date.updated2015-11-26T13:01:31Z
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Helsetjeneste- og helseadministrasjonsforskning: 806
dc.subject.nsiVDP::Midical sciences: 700::Health sciences: 800::Health service and health administration research: 806
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801
dc.subject.nsiVDP::Midical sciences: 700::Health sciences: 800::Community medicine, social medicine: 801
dc.identifier.doi10.1186/1745-6215-15-256
dc.identifier.cristin1151678


Tilhørende fil(er)

Thumbnail
Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel