Misoprostol ved igangsetting av fødsel
Ringrike, Tove; Samdal, Kristian; Lyngstadaas, Anita; Johansen, Karianne; Heimstad, Runa; Tuveng, Jon; Eriksson, Ane Gerda Zahl; Halvorsen, Marit; Gjertsen, Marianne Klemp
Peer reviewed, Research report
Permanent lenke
http://hdl.handle.net/11250/2378294Utgivelsesdato
2009-03Metadata
Vis full innførselSamlinger
Originalversjon
Rapport fra Kunnskapssenteret 3/2009Sammendrag
1-PAGE KEY MESSAGES ***
BACKGROUND
Approximately 55 000 children are born in Norway each year. It is sometimes necessary to induce labour artificially. With respect to induction with drugs, misoprostol and dinoprostone are used irrespective of whether the cervix is mature or not, while oxytocin only is used when the cervix is mature. The Norwegian Board of Health Supervision asked The Norwegian Knowledge Centre for the health Services to systematically review the efficacy and safety of misoprostol for induction of labour.
METHOD
This report is an overview of systematic reviews. We performed systematic searches in Cochrane Library, CRD and Ovid Medline and Embase. All included publications were evaluated for quality. In addition, we evaluated the quality of the evidence and the strength of recommendations for selected outcomes.
We also performed an evaluation of legal aspects regarding the use of misoprostol for induction of labour.
RESULTS
Five systematic reviews met our inclusion criteria. In the systematic reviews misoprostol was given vaginally, orally, sublingually or buccally. Misoprostol was used in different dosages and dosage intervals from study to study.
Our main findings were that vaginal and oral misoprostol was at least as effective as dinoprostone in inducing labour within 24 hours. However, it may have increased frequency of adverse events such as uterine hyperstimulation both without and with changes in fetal heart rate.
CONCLUSION
It may appear that safety is more sensitive to the dose of misoprostol than efficacy. For sublingual and buccal administration of misoprostol the amount of data were limited and we were not able to conclude on efficacy and safety.
Utgiver
Norwegian Knowledge Centre for the Health ServicesSerie
Rapport fra Kunnskapssenteret3/2009
Beslektede innførsler
Viser innførsler beslektet ved tittel, forfatter og emneord.
-
Helseeffekt av influensavaksine til eldre og kronisk syke
Vist, Gunn E.; Sæterdal, Ingvil; Johansen, Marit; Bergsaker, Marianne Riise; Hauge, Siri Helene; Fretheim, Atle (Rapport fra Kunnskapssenteret, Peer reviewed; Research report, 2009-05-20)BAKGRUNN: På oppdrag fra allmennpraktiker Ottar Grimstad ble vi bedt om å finne dokumentasjonsgrunnlaget for effekten av influensavaksinering av eldre og personer med kronisk sykdom. METODE: Vi søkte etter systematiske ... -
Gentester for brystkreft og eggstokkreft.
Juvet, Lene Kristine; Norderhaug, Inger Natvig (Rapport fra Kunnskapssenteret, Peer reviewed; Research report, 2008-02)SUMMARY IN ENGLISH IN THE REPORT. ********************************* Brystkreft og eggstokkreft er blant de hyppigste kreftformene som rammer kvinner i Norge. Man regner med at 5−10 % av disse krefttilfellene skyldes arv. ... -
HPV RNA-test for livmorhalskreft
Sæterdal, Ingvil von Mehren; Juvet, Lene Kristine; Norderhaug, Inger Natvig (Rapport fra Kunnskapssenteret, Peer reviewed; Research report, 2008-01)3-PAGE EXECUTIVE SUMMARY Background Cervical cancer is the second most common cancer in women world-wide and affects about 300 women in Norway each year. Cervical cancer develops through cellular abnormalities in the ...