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dc.contributor.authorMonsen, Anne Lise Bjørke
dc.contributor.authorUlvik, Arve
dc.contributor.authorNilsen, Roy Miodini
dc.contributor.authorMidttun, Øivind
dc.contributor.authorRoth, Christine
dc.contributor.authorMagnus, Per
dc.contributor.authorStoltenberg, Camilla
dc.contributor.authorVollset, Stein Emil
dc.contributor.authorReichborn-Kjennerud, Ted
dc.contributor.authorUeland, Per Magne
dc.date.accessioned2017-02-06T15:20:26Z
dc.date.available2017-02-06T15:20:26Z
dc.date.created2017-01-05T13:23:13Z
dc.date.issued2016
dc.identifier.citationNutrients. 2016, 8 (12), .
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11250/2429668
dc.description.abstractMaternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, B vitamin status, and inflammatory markers in a group of healthy pregnant women. Cobalamin, folate, pyridoxal 5'-phosphate, and riboflavin; and the metabolic markers homocysteine, methylmalonic acid, and 3-hydroxykynurenine/xanthurenic acid ratio (HK/XA); and markers of cellular inflammation, neopterin and kynurenine/tryptophan ratio (KTR) were determined in pregnancy week 18 and related to pre-pregnancy body mass index (BMI), in 2797 women from the Norwegian Mother and Child Cohort Study (MoBa). Pre-pregnancy BMI was inversely related to folate, cobalamin, pyridoxal 5'-phosphate (PLP), and riboflavin (p < 0.001), and associated with increased neopterin and KTR levels (p < 0.001). Inflammation seemed to be an independent predictor of low vitamin B6 status, as verified by low PLP and high HK/XA ratio. A high pre-pregnancy BMI is a risk factor for low B vitamin status and increased cellular inflammation. As an optimal micronutrient status is vital for normal fetal development, the observed lower B vitamin levels may contribute to adverse pregnancy outcomes associated with maternal obesity and B vitamin status should be assessed in women with high BMI before they get pregnant.
dc.language.isoeng
dc.relation.urihttp://www.mdpi.com/2072-6643/8/12/776
dc.titleImpact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study
dc.typePeer reviewed
dc.typeJournal article
dc.source.pagenumber15
dc.source.volume8
dc.source.journalNutrients
dc.source.issue12
dc.identifier.doi10.3390/nu8120776
dc.identifier.cristin1421656
cristin.unitcode7502,3,12,0
cristin.unitcode7502,5,0,0
cristin.unitcode7502,2,0,0
cristin.unitcode7502,3,0,0
cristin.unitnamePsykiske lidelser
cristin.unitnameHelsedata og digitalisering
cristin.unitnameInstituttledelse
cristin.unitnamePsykisk og fysisk helse
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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