Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study
dc.contributor.author | Monsen, Anne Lise Bjørke | |
dc.contributor.author | Ulvik, Arve | |
dc.contributor.author | Nilsen, Roy Miodini | |
dc.contributor.author | Midttun, Øivind | |
dc.contributor.author | Roth, Christine | |
dc.contributor.author | Magnus, Per | |
dc.contributor.author | Stoltenberg, Camilla | |
dc.contributor.author | Vollset, Stein Emil | |
dc.contributor.author | Reichborn-Kjennerud, Ted | |
dc.contributor.author | Ueland, Per Magne | |
dc.date.accessioned | 2017-02-06T15:20:26Z | |
dc.date.available | 2017-02-06T15:20:26Z | |
dc.date.created | 2017-01-05T13:23:13Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Nutrients. 2016, 8 (12), . | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | http://hdl.handle.net/11250/2429668 | |
dc.description.abstract | Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, B vitamin status, and inflammatory markers in a group of healthy pregnant women. Cobalamin, folate, pyridoxal 5'-phosphate, and riboflavin; and the metabolic markers homocysteine, methylmalonic acid, and 3-hydroxykynurenine/xanthurenic acid ratio (HK/XA); and markers of cellular inflammation, neopterin and kynurenine/tryptophan ratio (KTR) were determined in pregnancy week 18 and related to pre-pregnancy body mass index (BMI), in 2797 women from the Norwegian Mother and Child Cohort Study (MoBa). Pre-pregnancy BMI was inversely related to folate, cobalamin, pyridoxal 5'-phosphate (PLP), and riboflavin (p < 0.001), and associated with increased neopterin and KTR levels (p < 0.001). Inflammation seemed to be an independent predictor of low vitamin B6 status, as verified by low PLP and high HK/XA ratio. A high pre-pregnancy BMI is a risk factor for low B vitamin status and increased cellular inflammation. As an optimal micronutrient status is vital for normal fetal development, the observed lower B vitamin levels may contribute to adverse pregnancy outcomes associated with maternal obesity and B vitamin status should be assessed in women with high BMI before they get pregnant. | |
dc.language.iso | eng | |
dc.relation.uri | http://www.mdpi.com/2072-6643/8/12/776 | |
dc.title | Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study | |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.source.pagenumber | 15 | |
dc.source.volume | 8 | |
dc.source.journal | Nutrients | |
dc.source.issue | 12 | |
dc.identifier.doi | 10.3390/nu8120776 | |
dc.identifier.cristin | 1421656 | |
cristin.unitcode | 7502,3,12,0 | |
cristin.unitcode | 7502,5,0,0 | |
cristin.unitcode | 7502,2,0,0 | |
cristin.unitcode | 7502,3,0,0 | |
cristin.unitname | Psykiske lidelser | |
cristin.unitname | Helsedata og digitalisering | |
cristin.unitname | Instituttledelse | |
cristin.unitname | Psykisk og fysisk helse | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 |
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