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dc.contributor.authorNygaard, Unni Cecilie
dc.contributor.authorSamuelsen, Mari
dc.contributor.authorMarioara, Calin Daniel
dc.contributor.authorLøvik, Martinus
dc.date.accessioned2019-11-08T15:00:55Z
dc.date.available2019-11-08T15:00:55Z
dc.date.created2013-10-22T09:56:09Z
dc.date.issued2013
dc.identifier.citationBioMed Research International. 2013, 2013 .
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/11250/2627488
dc.description.abstractThere is a growing concern for the possible health impact of nanoparticles. The main objective of this study was to investigate the allergy-promoting capacity of four different carbon nanofiber (CNF) samples in an injection and an airway mouse model of allergy. Secondly, the potency of the CNF was compared to the previously reported allergy-promoting capacity of carbon nanotubes (CNT) in the airway model. Ultrafine carbon black particles (ufCBP) were used as a positive control. Particles were given together with the allergen ovalbumin (OVA) either by subcutaneous injection into the footpad or intranasally to BALB/cA mice. After allergen booster, OVA-specific IgE, IgG1, and IgG2a in serum were measured. In the airway model, inflammation was determined as influx of inflammatory cells (eosinophils, neutrophils, lymphocytes, and macrophages) and by mediators (MCP-1 and TNF- present in bronchoalveolar fluid (BALF)). CNF and CNT both increased OVA-specific IgE levels in the two models, but in the airway model, the CNT gave a significantly stronger IgE response than the CNF. Furthermore, the CNT and not the CNF promoted eosinophil lung inflammation. Our data therefore suggest that nanotube-associated properties are particularly potent in promoting allergic responses.
dc.description.abstractCarbon nanofibers have IgE adjuvant capacity but are less potent than nanotubes in promoting allergic airway responses
dc.language.isoeng
dc.relation.urihttp://www.hindawi.com/journals/bmri/2013/476010/
dc.titleCarbon nanofibers have IgE adjuvant capacity but are less potent than nanotubes in promoting allergic airway responses
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.subject.nsiVDP::Medisinsk immunologi: 716
dc.subject.nsiVDP::Medical immunology: 716
dc.source.pagenumber12
dc.source.volume2013
dc.source.journalBioMed Research International
dc.identifier.doi10.1155/2013/476010
dc.identifier.cristin1059373
cristin.unitcode7502,4,3,0
cristin.unitcode7502,0,0,0
cristin.unitnameAvdeling for toksikologi og risiko
cristin.unitnameFolkehelseinstituttet
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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