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dc.contributor.authorLindeman, Birgitte
dc.contributor.authorJohansson, Ylva
dc.contributor.authorAndreassen, Mathilda
dc.contributor.authorHusøy, Trine
dc.contributor.authorDirven, Hubert
dc.contributor.authorHofer, Tim
dc.contributor.authorKnutsen, Helle Katrine
dc.contributor.authorCaspersen, Ida Henriette
dc.contributor.authorVejrup, Kristine
dc.contributor.authorPaulsen, Ragnhild Elisabeth
dc.contributor.authorAlexander, Jan
dc.contributor.authorForsby, Anna
dc.contributor.authorMyhre, Oddvar
dc.date.accessioned2021-05-12T06:45:01Z
dc.date.available2021-05-12T06:45:01Z
dc.date.created2021-05-10T08:52:12Z
dc.date.issued2021
dc.identifier.citationReproductive Toxicology. 2021, 101 93-114.
dc.identifier.issn0890-6238
dc.identifier.urihttps://hdl.handle.net/11250/2755042
dc.description.abstractThere is a worldwide concern on adverse health effects of dietary exposure to acrylamide (AA) due to its presence in commonly consumed foods. AA is formed when carbohydrate rich foods containing asparagine and reducing sugars are prepared at high temperatures and low moisture conditions. Upon oral intake, AA is rapidly absorbed and distributed to all organs. AA is a known human neurotoxicant that can reach the developing foetus via placental transfer and breast milk. Although adverse neurodevelopmental effects have been observed after prenatal AA exposure in rodents, adverse effects of AA on the developing brain has so far not been studied in humans. However, epidemiological studies indicate that gestational exposure to AA impair foetal growth and AA exposure has been associated with reduced head circumference of the neonate. Thus, there is an urgent need for further research to elucidate whether pre- and perinatal AA exposure in humans might impair neurodevelopment and adversely affect neuronal function postnatally. Here, we review the literature with emphasis on the iden-tification of critical knowledge gaps in relation to neurodevelopmental toxicity of AA and its mode of action and we suggest research strategies to close these gaps to better protect the unborn child.
dc.language.isoeng
dc.titleDoes the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber93-114
dc.source.volume101
dc.source.journalReproductive Toxicology
dc.identifier.doi10.1016/j.reprotox.2021.02.006
dc.identifier.cristin1909051
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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