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dc.contributor.authorCascella, Vincenza
dc.contributor.authorAndreassen, Monica
dc.contributor.authorHusøy, Trine
dc.contributor.authorDirven, Hubert
dc.contributor.authorLie, Bernt
dc.date.accessioned2021-09-10T06:33:33Z
dc.date.available2021-09-10T06:33:33Z
dc.date.created2018-12-04T18:24:17Z
dc.date.issued2018
dc.identifier.citationLinköping Electronic Conference Proceedings. 2018, (153), 148-155.
dc.identifier.issn1650-3686
dc.identifier.urihttps://hdl.handle.net/11250/2775066
dc.description.abstractTriclosan (TCS) has been used as an antibacterial additive in several personal care products (PCPs) for more than 40 years. In animals studies, it is observed that TCS in rats has adverse effects on the endocrine function and thyroid hormone homeostasis, and intensify antibiotic resistance. In human studies, significant levels of TCS are detected in human plasma and breast milk. In this study, a Physiologically Based Pharmacokinetic or Toxicokinetic (PBP-K/TK) model is developed to describe the concentration of triclosan in human organs after exposure through the skin (dermal) or orally. Several studies have been conducted on toxicokinetics of TCS, but there is a lack of information on parameters for PBPK models. In this paper, focus is on finding parameters for TCS to be used in the PBPK model. In a first case, the PBPK model was based on data for TCS and the structurally related chemical Bisphenol A (BPA), in a second case, partition coefficients were found using Poulin’s method. The simulations were carried out using MATLAB, and the results for the two cases are compared.
dc.description.abstractModeling and Simulation of Triclosan Kinetics and Distribution in Humans Using PBPK Model
dc.language.isoeng
dc.titleModeling and Simulation of Triclosan Kinetics and Distribution in Humans Using PBPK Model
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber148-155
dc.source.journalLinköping Electronic Conference Proceedings
dc.source.issue153
dc.identifier.doi10.3384/ecp18153148
dc.identifier.cristin1639145
cristin.unitcode7502,4,3,0
cristin.unitnameAvdeling for toksikologi og risiko
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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