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dc.contributor.authorSteinberg, Stacy
dc.contributor.authorStefansson, Hreinn
dc.contributor.authorJonsson, Thorlakur
dc.contributor.authorJohannsdottir, Hrefna
dc.contributor.authorIngason, Andrés
dc.contributor.authorHelgason, Hannes
dc.contributor.authorSulem, Patrick
dc.contributor.authorMagnusson, Olafur Th
dc.contributor.authorGudjunsson, Sigurjon A
dc.contributor.authorUnnsteinsdottir, Unnur
dc.contributor.authorKong, Augustine
dc.contributor.authorHelisalmi, Seppo
dc.contributor.authorSoininen, Hilkka
dc.contributor.authorLah, James J
dc.contributor.authorAarsland, Dag
dc.contributor.authorFladby, Tormod
dc.contributor.authorUlstein, Ingun
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorSando, Sigrid Botne
dc.contributor.authorWhite, Linda
dc.contributor.authorKnudsen, Gun Peggy
dc.contributor.authorWestlye, Lars Tjelta
dc.contributor.authorSelbæk, Geir
dc.contributor.authorGiegling, Ina
dc.contributor.authorHampel, Harald
dc.contributor.authorHiltunen, Mikko
dc.contributor.authorLevey, AIlan I.
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorRujescu, Dan
dc.contributor.authorJonsson, Palmi V.
dc.contributor.authorBjornsson, Sigurbjorn
dc.contributor.authorSnaedal, Jon
dc.contributor.authorStefánsson, Kári
dc.date.accessioned2015-04-14T11:16:10Z
dc.date.accessioned2015-08-13T07:26:04Z
dc.date.available2015-04-14T11:16:10Z
dc.date.available2015-08-13T07:26:04Z
dc.date.issued2015
dc.identifier.citationNature Genetics 2015
dc.identifier.issn1546-1718
dc.identifier.urihttp://hdl.handle.net/11250/296499
dc.description-
dc.description.abstractWe conducted a search for rare, functional variants altering susceptibility to Alzheimer’s disease that exploited knowledge of common variants associated with the same disease. We found that loss-of-function variants in ABCA7 confer risk of Alzheimer’s disease in Icelanders (odds ratio (OR) = 2. 2, P = 2.2× 10- 3) and discovered that the association replicated in study groups from Europe and the United States (combined OR = 2.03, P = 6.8×10-5).
dc.language.isoeng
dc.titleLoss-of-function variants in ABCA7 confer risk of Alzheimer’s disease
dc.typeJournal article
dc.date.updated2015-04-14T11:16:10Z
dc.identifier.doidoi:10.1038/ng.3246
dc.identifier.cristin1234523


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