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dc.contributor.authorUeland, Grethe Åstrøm
dc.contributor.authorKellmann, Ralf
dc.contributor.authorDavidsen, Melissa Jørstad
dc.contributor.authorViste, Kristin
dc.contributor.authorHusebye, Eystein Sverre
dc.contributor.authorAlmås, Bjørg
dc.contributor.authorStorr, Helen L.
dc.contributor.authorSagen, Jørn Vegard
dc.contributor.authorMellgren, Gunnar
dc.contributor.authorJuliusson, Pétur Benedikt
dc.contributor.authorMethlie, Paal
dc.date.accessioned2022-07-26T13:24:55Z
dc.date.available2022-07-26T13:24:55Z
dc.date.created2021-05-20T15:32:13Z
dc.date.issued2021
dc.identifier.citationJournal of the Endocrine Society (JES). 2021, 5 (5), 1-8.
dc.identifier.issn2472-1972
dc.identifier.urihttps://hdl.handle.net/11250/3008653
dc.description.abstractAbstract Background:Diagnosing Cushing syndrome (CS) can be challenging. The 24-hour urine free cortisol (UFC) measurement is considered gold standard. This is a laborious test, de-pendent on correct urine collection. Late-night salivary cortisol is easier and is used as a screening test for CS in adults, but has not been validated for use in children. Objective:To define liquid chromatography tandem mass spectrometry (LC-MS/MS)-based cutoff values for bedtime and morning salivary cortisol and cortisone in children, and validate the results in children with and without CS. Methods:Bedtime and morning salivary samples were collected from 320 healthy chil-dren aged 4 to 16 years. Fifty-four patients from the children’s outpatient obesity clinic and 3 children with pituitary CS were used for validation. Steroid hormones were as-sayed by LC-MS/MS. Cutoff levels for bedtime salivary cortisol and cortisone were de-fined by the 97.5% percentile in healthy subjects. Results:Bedtime cutoff levels for cortisol and cortisone were 2.4 and 12.0 nmol/L, re-spectively. Applying these cutoff levels on the verification cohort, 1 child from the obesity clinic had bedtime salivary cortisol exceeding the defined cutoff level, but normal sal-ivary cortisone. All 3 children with pituitary CS had salivary cortisol and cortisone far above the defined bedtime cutoff levels. Healthy subjects showed a significant decrease in salivary cortisol from early morning to bedtime.
dc.language.isoeng
dc.titleBedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber1-8
dc.source.volume5
dc.source.journalJournal of the Endocrine Society (JES)
dc.source.issue5
dc.identifier.doi10.1210/jendso/bvab033
dc.identifier.cristin1911115
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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