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dc.contributor.authorHusebye, Elisabeth Synnøve Nilsen
dc.contributor.authorRiedel, Bettina Maria Ingeborg
dc.contributor.authorMonsen, Anne-Lise Bjørke
dc.contributor.authorSpigset, Olav
dc.contributor.authorDaltveit, Anne Kjersti Nesje
dc.contributor.authorGilhus, Nils Erik
dc.contributor.authorBjørk, Marte-Helene
dc.date.accessioned2022-08-01T06:59:05Z
dc.date.available2022-08-01T06:59:05Z
dc.date.created2021-10-21T10:37:08Z
dc.date.issued2021
dc.identifier.citationEpilepsia. 2021, 1-13.
dc.identifier.issn0013-9580
dc.identifier.urihttps://hdl.handle.net/11250/3009402
dc.description.abstractObjective Antiseizure medication (ASM) use interacts with vitamin B status in nonpregnant epilepsy populations. We aimed to examine the association between ASM and vitamin B status in pregnant women with epilepsy. Methods We performed a cross-sectional study of pregnancies in women with epilepsy enrolled in the Norwegian Mother, Father and Child Cohort Study from 1999 to 2008. Data on ASM and vitamin supplement use were collected from questionnaires. We analyzed maternal plasma concentrations of ASM and metabolites of folate, including unmetabolized folic acid (UMFA), riboflavin (vitamin B2), pyridoxine (vitamin B6), and niacin (vitamin B3) during gestational weeks 17–19. Results We included 227 singleton pregnancies exposed to ASM with available plasma samples (median maternal age 29 years, range 18 to 41 years). From the preconception period to gestational week 20, any supplement of folic acid was reported in 208 of pregnancies (94%), riboflavin in 72 (33%), pyridoxine in 77 (35%), and niacin in 45 (20%). High ASM concentrations correlated with high concentrations of UMFA and inactive folate metabolites, and with low concentrations of riboflavin and metabolically active pyridoxine. There was no association between ASM and niacin status. Significance ASM concentrations during pregnancy were associated with vitamin B status in pregnant women with epilepsy. Additional studies are needed to determine the clinical impact of these findings, and to define the optimal vitamin doses that should be recommended to improve pregnancy outcomes.
dc.language.isoeng
dc.titleVitamin B status and association with antiseizure medication in pregnant women with epilepsy
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber1-13
dc.source.journalEpilepsia
dc.identifier.doi10.1111/epi.17076
dc.identifier.cristin1947517
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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