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dc.contributor.authorStensen, Dina Benedicte Berg
dc.contributor.authorSmåbrekke, Lars
dc.contributor.authorOlsen, Karina
dc.contributor.authorGrimnes, Guri
dc.contributor.authorNielsen, Christopher Sivert
dc.contributor.authorSollid, Johanna U Ericson
dc.contributor.authorSimonsen, Gunnar Skov
dc.contributor.authorAlmås, Bjørg
dc.contributor.authorFurberg, Anne-Sofie
dc.date.accessioned2022-08-01T08:54:44Z
dc.date.available2022-08-01T08:54:44Z
dc.date.created2021-03-09T10:37:32Z
dc.date.issued2021
dc.identifier.citationEuropean Journal of Endocrinology. 2021, 184 (2), 337-346.
dc.identifier.issn0804-4643
dc.identifier.urihttps://hdl.handle.net/11250/3009539
dc.description.abstractObjective: Staphylococcus aureus is a major human pathogen, and nasal carriers have an increased risk for infection and disease. The exploration of host determinants for nasal carriage is relevant to decrease infection burden. Former studies demonstrate lower carriage prevalence in women and among users of progestin-only contraceptives. The aim of this study was to investigate the possible associations between circulating sex-steroid hormones and nasal carriage of Staphylococcus aureus in a general population. Methods: In the population-based sixth Tromsø study (2007–2008) nurses collected nasal swab samples from 724 women aged 30–87 not using any exogenous hormones, and 700 of the women had a repeated nasal swab taken (median interval 28 days). We analysed a panel of serum sex-steroids by liquid chromatography tandem mass spectrometry, and collected information about lifestyle, health and anthropometric measures. Multivariable logistic regression was used to study the association between circulating sex-steroids and Staphylococcus aureus carriage (one swab) and persistent carriage (two swabs), while adjusting for potential confounding factors. Women in luteal phase were excluded in the analysis of androgens. Results: Staphylococcus aureus persistent nasal carriage prevalence was 22%. One standard deviation increase in testosterone and bioavailable testosterone was associated with lower odds of persistent nasal carriage, (OR = 0.57; 95% CI = 0.35–0.92 and OR = 0.52, 95% CI = 0.30–0.92) respectively. Analysis stratified by menopause gave similar findings. Persistent carriers had lower average levels of andros tenedione and DHEA, however, not statistically significant. Conclusion: This large population-based study supports that women with lower levels of circulating testosterone may have increased probability of Staphylococcus aureus persistent carriage.
dc.language.isoeng
dc.relation.urihttps://doi.org/10.1530/EJE-20-0877
dc.titleCirculating sex-steroids and Staphylococcus aureus nasal carriage in a general female population
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber337-346
dc.source.volume184
dc.source.journalEuropean Journal of Endocrinology
dc.source.issue2
dc.identifier.doi10.1530/EJE-20-0877
dc.identifier.cristin1896577
dc.relation.projectHelse Nord RHF: HNF1457–19
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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