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dc.contributor.authorEid, Karine
dc.contributor.authorTorkildsen, Øivind
dc.contributor.authorAarseth, Jan Harald
dc.contributor.authorAalstad, Mari
dc.contributor.authorBhan, Alok
dc.contributor.authorCelius, Elisabeth Gulowsen
dc.contributor.authorCortese, Marianna
dc.contributor.authorDaltveit, Anne Kjersti Nesje
dc.contributor.authorHolmøy, Trygve
dc.contributor.authorMyhr, Kjell-Morten
dc.contributor.authorRiise, Trond
dc.contributor.authorSchuler, Stephan
dc.contributor.authorTorkildsen, Cecilie Fredvik
dc.contributor.authorWergeland, Stig
dc.contributor.authorGilhus, Nils Erik
dc.contributor.authorBjørk, Marte-Helene
dc.date.accessioned2022-12-14T08:05:51Z
dc.date.available2022-12-14T08:05:51Z
dc.date.created2022-05-13T12:40:57Z
dc.date.issued2022
dc.identifier.citationJournal of Neurology, Neurosurgery and Psychiatry. 2022, 93 (6), 645-650.
dc.identifier.issn0022-3050
dc.identifier.urihttps://hdl.handle.net/11250/3037596
dc.description.abstractObjective: To study whether exposure to childhood emotional, sexual or physical abuse is associated with subsequent multiple sclerosis (MS) development. Methods: A nationwide, prospective cohort study based on participants in the Norwegian Mother, Father and Child cohort study. Enrolment took place 1999-2008, with follow-up until 31 December 2018. Childhood abuse before age 18 years was obtained from self-completed questionnaires. We identified MS diagnoses through data-linkage with national health registries and hospital records. The Cox model was used to estimate HRs for MS with 95% CIs, adjusting for confounders and mediators. Results: In this prospective cohort study, 14 477 women were exposed to childhood abuse and 63 520 were unexposed. 300 women developed MS during the follow-up period. 71 of these (24%) reported a history of childhood abuse, compared with 14 406 of 77 697 (19%) women that did not develop MS. Sexual abuse (HR 1.65, 95% CI 1.13 to 2.39) and emotional abuse (HR 1.40, 95% CI 1.03 to 1.90) in childhood were both associated with an increased risk of developing MS. The HR of MS after exposure to physical abuse was 1.31 (95% CI 0.83 to 2.06). The risk of MS was further increased if exposed to two (HR 1.66, 95% CI 1.04 to 2.67) or all three abuse categories (HR 1.93, 95% CI 1.02 to 3.67). Interpretation: Childhood sexual and emotional abuse were associated with an increased risk of developing MS. The risk was higher when exposed to several abuse categories, indicating a dose-response relationship. Further studies are needed to identify underlying mechanisms. Keywords: multiple sclerosis; trauma, psychol seque. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.language.isoeng
dc.titleAssociation of adverse childhood experiences with the development of multiple sclerosis
dc.title.alternativeAssociation of adverse childhood experiences with the development of multiple sclerosis
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.description.versionpublishedVersion
dc.source.pagenumber645-650
dc.source.volume93
dc.source.journalJournal of Neurology, Neurosurgery and Psychiatry
dc.source.issue6
dc.identifier.doi10.1136/jnnp-2021-328700
dc.identifier.cristin2024330
dc.relation.projectNorges forskningsråd: 288164
dc.relation.projectHelse Vest RHF: F-12503
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.fulltextoriginal
cristin.qualitycode2


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