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dc.contributor.authorSkarpsno, Eivind S.
dc.contributor.authorMork, Paul Jarle
dc.contributor.authorNilsen, Tom Ivar Lund
dc.contributor.authorSteingrímsdóttir, Ólöf Anna
dc.contributor.authorZwart, John Anker
dc.contributor.authorNilsen, Kristian Bernhard
dc.date.accessioned2022-07-26T06:48:03Z
dc.date.available2022-07-26T06:48:03Z
dc.date.created2019-07-26T12:47:23Z
dc.date.issued2019
dc.identifier.citationSleep. 2019, 42 (9), .
dc.identifier.issn0161-8105
dc.identifier.urihttps://hdl.handle.net/11250/3008480
dc.description.abstractStudy Objectives To examine independent associations of sleeplessness and high-sensitivity C-reactive protein (hsCRP) with risk of chronic musculoskeletal pain, and to explore the joint effect of sleeplessness and hsCRP on risk of chronic musculoskeletal pain. Methods A population-based prospective study of 3214 women and 3142 men (mean age: 55.4, range: 32–87) without severe chronic musculoskeletal pain and with hsCRP ≤ 10 mg/L at baseline in 2007–2008. Modified Poisson regression was used to calculate adjusted risk ratios (RRs) with 95% confidence intervals (CIs) for any chronic musculoskeletal pain and chronic widespread pain (CWP) at follow-up in 2015–2016 associated with self-reported sleeplessness and hsCRP at baseline. Results Compared with persons without sleeplessness, women and men reporting often/or always sleeplessness had RRs of CWP of 2.53 (95% CI: 1.94–3.29) and 2.48 (95% CI: 1.63–3.77), respectively. There was no clear association between hsCRP and risk of any chronic musculoskeletal pain or CWP. Joint effect analyses using persons without sleeplessness and with a hsCRP < 1.00 mg/L as the reference gave RRs for chronic musculoskeletal pain of 1.73 (95% CI: 1.26–2.37) for those with often/always sleeplessness and hsCRP < 1.00 mg/L; 1.01 (95% CI: 0.78–1.32) for those without sleeplessness and hsCRP ≥3.00 mg/L; and 2.47 (95% CI: 1.79–3.40) if they had both often/always sleeplessness and hsCRP ≥ 3.00 mg/L. The corresponding RRs for CWP were 1.89 (95% CI: 1.27–2.83), 0.96 (95% CI: 0.68–1.37), and 2.83 (95% CI: 1.91–4.20), respectively. Conclusions These results suggest that there is an interplay between sleeplessness and hsCRP on risk of any chronic musculoskeletal pain and CWP.
dc.language.isoeng
dc.titleThe interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionacceptedVersion
dc.source.pagenumber8
dc.source.volume42
dc.source.journalSleep
dc.source.issue9
dc.identifier.doi10.1093/sleep/zsz127
dc.identifier.cristin1712889
cristin.unitcode7502,3,2,0
cristin.unitnameAvdeling for kroniske sykdommer og aldring
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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